The Chiefs have the victories in the playoffs against the Titans but lately, the Titans have won most games in the series against Kansas City.
The Titans will be without veteran running back DeMarco Murray for the second consecutive game as he continues to battle a knee injury.
Playoff success has not been synonymous with Kansas City or Tennessee recently, but one of them will advance and take on either the second-seeded Pittsburgh Steelers (13-3) or top-seeded New England Patriots (13-3) in the divisional round.
The Titans are in the playoffs for the first time in 9 years.
The Kansas City Chiefs have completed the greatest National Football League postseason collapse since. well, since the last National Football League postseason game. Since the move to Tennessee, the Titans have gone 4-1 against the Chiefs when traveling to Kansas City.
While that would not be ideal initially, they would get the chance to host the Saints in the NFC Championship Game if both teams make it to that point. However, Alex Smith and company won their last four games of the season and appear to be firing on all cylinders heading into the playoffs.
The Chiefs opened as seven-point favorites; the total was 46 early in the week, according to sportsbooks monitored by OddsShark. That bodes well for the Chiefs, as Mariota has yet to prove he can play well under stress.
Since coming to Kansas City in 2013, head coach Andy Reid is 1-2 against the Titans. The Titans have had their own issues this season giving up more points than they've scored this season.