Last year, the Bay State was ranked second behind Hawaii, which had held the No. 1 spot for the past five years.
There is also a significant variation in primary care physicians, with a almost two-to-one ratio between the states with the highest and lowest concentrations.
Along with earning the top ranking overall, MA was No.1 when it came to how many young children and adolescents received immunizations, having the lowest percentage of the population uninsured at just 2.7 percent, the number of dentists per 100,000 people and the number of health providers per 100,000 people.
Here's the list of the 10 unhealthiest states, according to the report.
One particularly troubling trend: The rate of premature death rose for the third year in a row. In the past five years, MA saw a 69 percent increase in drug deaths, or an addition of 8-plus deaths per 100,000 people.
Oklahoma's smoking rate has declined 25 percent in the past five years.
According to the report, Florida and Utah "experienced the largest rank improvements since a year ago", as both states rose four slots to now being number 32 and number four in the country, respectively. Other top healthiest states, based on wide ranging factors from vaccination rates, smoking rates and air pollution levels, were Hawaii, Vermont, Utah and CT.
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At the bottom of the rankings were Mississippi, Louisiana, Arkansas, Alabama and West Virginia.