Whitman joined the company in 2011, after serving as the head of eBay.
HPE was the result of that split, with Whitman taking the CEO role and Dion Weisler, then executive VP of HP's old printing and PC business, taking the CEO role of HP Inc. Two years ago, she oversaw the biggest corporate split (by revenue) in history, breaking HP and Hewlett-Packard Enterprise apart, staying on as CEO of HPE.
"I'm incredibly proud of all we've accomplished since I joined HP in 2011", Whitman said in a statement.
"I like a more nimble, agile company and I have no plans to leave HPE", Whitman said at the time when pertinent rumors surfaced. "Now is the right time for Antonio and a new generation of leaders to take the reins of HPE".
Andreessen and others expect Whitman's next move could be in politics-she unsuccessfully ran for Governor of California in 2010-though in our August interview she said, "I'm definitely not doing that".
XAutoplay: On | OffThe company said Antonio Neri, who was named company president in June, will replace Whitman. She continued on as CEO of HPE and sat on the board of HP until July 2017. "I have tremendous confidence that they will continue to build a great company that will thrive well into the future". Whitman took to Twitter to announce she was going to remain as the company's CEO. He has been with the company since 1995.
In another she said: "So let me make this as clear as I can".
Marc Andreessen, the venture capitalist who serves on HPE's board with Whitman, told me at the time, "Uber would have been very lucky to get her, and I'm thrilled that they didn't". He hasn't disclosed any plans he might have as would-be CEO, but that should come shortly.