City's goalkeeper Ederson reacted quickly however, racing out to close Mane down before he could get a shot away.
"It's so important for us to feel that we have one guy to help the central defenders". I've had it before when you have to jump into people's feet and you have to be courageous. Hopefully he can come back as soon as possible.
"Obviously we want to do well in four, so it is very hard to do it in the four".
City were already leading 1-0 at the time through Aguero's opener and went on to win comfortably with doubles from Jesus and Leroy Sane.
"After that we played very well, took control of the game".
A number of City's players caught the eye but link-up play between strikers Aguero and Jesus was highly encouraging for boss Pep Guardiola.
"I think after the first goal we took more control of the game".
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Liverpool midfielder Georginio Wijnaldum said the visitors had not responded well after the red card.
The Dutchman said: "You hope it never happens again but things can happen in a game and we must make sure, if it happens again, we do better with 10 men than we did".
"It was an accident", the Liverpool manager told reporters.
The kick was evidently accidental, but Mane received a red card for the incident from referee John Moss, a decision that caused a lot of debate on social media.
As Liverpool fans, we can pray that this was just one of those matches that will give the team a reality check and play a part in propelling our team to achieving their targets for this season. "We are strong. Thanks for all your messages of support".
"A very unlucky situation".