Three ambulances attended but the young boy died at the scene.
Although a number of attempts were made the save the boy's life by both members of the public and paramedics it is understood he tragically died at the scene as a result of his extensive injuries.
Several media have reported witnesses saying they saw people covered in blood and heard screams.
Police were called after witnesses say they heard "blood-curdling" screams coming from the auto park of the Ibis hotel in Salford Quays on Thursday night (10 August).
Witnesses at the Ibis Hotel in Salford Quays near Manchester reported hearing "blood-curdling screams" after the incident, which police are saying was a "tragic accident".
Police Sergeant Brian Orr told the MEN: "This was a heart-breaking incident involving a young boy which has understandably left his family distraught and the thoughts of everyone in the SCIU are with them at this awful time".
Manchester incident believed to be centred on road traffic accident involving child
The incident is thought to have taken place in the auto park of the hotel, which is less than a mile from Manchester United's Old Trafford stadium.
More than 10 emergency vehicles were seen lined up outside the hotel after the incident. "Enquiries ongoing", police wrote.
The child is reported to have been hit by a vehicle in the hotel's rear auto park, which connects to a Marriott hotel next door.
"A woman was shouting hysterically and a children were screaming and crying".
Manchester police have been on heightened alert since a terrorist attack at Manchester Arena packed with thousands of concert-goers on May 22. Twenty-three people, mostly Grande's teenage fans and their relatives, were killed in the attack.
She described seeing police talking to a "little girl on a bench" who "appears to be wrapped in a towel".