This basically means that the capture function of programs like XSplit and OBS won't work with the game at fullscreen. Bungie has made clear that to help ensure that every player will have a fair shot at fun and glory in Destiny 2 on PC. Unfortunately, OBS and XSplit will not work in full screen. but they will work in windowed mode (and borderless windowed) in both Screen Capture and Window Capture modes; while similar applications like Dxtory and Razer Cortex will have similar limitations.
NVIDIA Shadowplay and AMD ReLive are supported.
OBS and XSplit Window Capture mode is supported.
This is explicitly because Bungie doesn't want third-party interference in the games.
Of course, it's probably important to note that this doesn't actually stop you from using Discord or other chat services to talk to teammates in Destiny 2.
According to Bungie's weekly update, the PC beta will include several of the same missions and modes found in the console beta such as the Homecoming story mission, Inverted Spire Strike, and the two competitive multiplayer modes, Countdown and Control.
Hardware Monitoring Framerate and statistics overlays, such as those provided by EVGA Precision XOC, MSi Afterburner, and Fraps, are not compatible with Destiny 2. Bungie warns people who use programs that rely on code being inserted into the game client.
The start of the beta period of "Destiny 2" for PC players is reportedly scheduled on Monday, Aug. 28, for those who pre-ordered the game, while the public will be able to enjoy it on Aug. 29.
Also, be sure not to miss all of last month's exclusive IGN First coverage of Destiny 2. If disabling such features does not resolve the performance impact, players may wish to try closing the third-party application.