The clash of second-placed Roma and first-placed Juventus at Olimpico on Sunday night.
Egypt global Mohamed Salah was influential as AS Roma fought back from a goal down to stun Juventus 3-1 in the Serie A on Sunday to move four points behind the leaders with two games to play.
Unbeaten in the league since mid-January, Juventus appeared to be cruising when Mario Lemina put it ahead in the 21st minute.
Roma have collected only one point from their last two Serie A home matches: the last time they remained winless in three consecutive league games on home soil was in March 2015.
The Giallorossi turned the match around in the second half when Stephan El Shaarawy's low shot crept into the bottom corner on 56 minutes and Radja Nainggolan then crashed home a third.
Napoli have a hard match away to Torino while Inter Milan will be under the third coach of the season when they host Sassuolo, hoping to end a run of seven games without a win that has seen them drop to seventh, outside the Europa League places. "The fact we drew with Atalanta and Torino, then lost here, it shows we've lost something in terms of concentration". We had a good first half, we just needed to stay organised.
Since Serie A was founded in 1929, no club has won more than five straight titles.
Allegri is clearly shuffling his pack ahead of Wednesday's Coppa Italia final against Lazio. Having also drawn in their last two, Juventus have not drawn three in a row since 2012.
De Rossi was first to the loose ball, stabbing it goalwards, which Buffon parried but the Roma midfielder remained alert to squeeze the rebound inside the far post.
Totti, who has mainly been restricted to cameo appearances, was left on the bench again on Sunday for what would have been his last appearance at Milan's San Siro.
Third place would mean a spot in the final playoff round where Italian teams have suffered six defeats in the last eight seasons.
Although Massimiliano Allegri's men are all but certain to retain their title regardless of this result thanks to their healthy lead and final two fixtures against Crotone and Bologna, victory here would allow them to fully switch their focus to the upcoming European final.
Inter's fourth successive defeat came in the first match since Stefano Pioli was sacked and the youth team coach, Stefano Vecchi, was put in charge.
"We have Juventus against Roma on Sunday, that's all I'm thinking about because we want to fight all the way to the end in this championship, and Roma comes first", said Totti. They're right. Inter shouldn't be seventh or eighth like it's been for five years.