Nick Kyrgios is forced to pull out of his Indian Wells quarter-final against Roger Federer due to a suspected bout of food poisoning.
It comes after the 21-year-old was spotted dipping into a courtside fan's chips during his doubles exit on Thursday.
Kyrgios is the first player in eight years to beat Djokovic in back-to-back hard court tournaments.
Kyrgios added: "After a restless night of being sick I have nothing left and to play a great champion like Roger, I need to be at my best to have a chance". He broke Nadal to go up 2-1 in the second set and won the match with a backhand return victor into the corner. A forehand volley sealed the set, and another forehand victor put Federer up a break at 2-1 in the second.
"If Nick wins that match and comes out of this quarter, I believe that it signals a real shift in the power and direction of men's tennis". Wednesday's match was just the fifth time they weren't opposing each other in a final.
"I'm the type of person that's going to have a fan base, and I'm the type of person that have people that don't really like me", he said. I still feel like I'm on the comeback but we'll see what the year brings.
It was the first time since their first match in 2004 that Federer and Nadal had met before the quarterfinals of a tournament. "But I think that's changing little by little, which I'm very happy about".
A break in the first game of the match was enough to give Kyrgios the opening set.
"I didn't think it was going to be that possible, to be quite honest, because the court is more jumpy here or more rough, let's say, so it's hard to put the ball away". "It's a nice feeling to win the last three".
Kyrgios announced his arrival on the world stage with a thunderous fourth-round win over Nadal in 2014 on Wimbledon's hallowed centre court before upending Federer on clay in Madrid the following year. Kyrgios will be empowered after snapping Djokovic's 19-match Indian Wells' winning streak. Look at that last forehand victor on match point, leaving Nadal in dumb disbelief.
In the women's draw, world No. 3 Karolina Pliskova reached the semi-finals after edging French Open champion Garbine Muguruza 7-6 (2), 7-6 (5).
The match point does not always sum up the match, but it did on Wednesday.