The attacking midfielder notched his 14th Premier League goal of the season in Spurs' 2-1 win over Southampton at White Hart Lane.
Pochettino had insisted before the game his squad had the resources to cope with the loss of Kane, who was ruled out for up to six weeks after picking up an ankle injury in the FA cup quarter-final victory over Millwall seven days previously.
The midfielder played a fantastic through ball to Son Heung-min, who was through on goal early on but he saw his shot well-saved by Fraser Forster. Son, who came in for Kane, squandered a couple of good chances but looked a threat. Let's break down three key ways the club can adapt to their new striker.
As he trudged off in the 30th minute Dele Alli was fouled in the area by Southampton skipper Steven Davis and Alli picked himself up to stroke home a penalty to put Spurs two up. Into the box he looks like a striker because he is more than clever, he is very smart.
It didn't matter though as Spurs held on for yet another crucial win as they try and obtain a top four spot this season which at the minute they are doing a good job of achieving.
Southampton (from): Forster, Taylor, Bertrand, Yoshida, Caceres, Gardos, Cedric, Hesketh, Romeu, Clasie, Ward-Prowse, Isgrove, Tadic, Redmond, Boufal, Lewis, Stephens, Hojbjerg, McQueen, Sims, Rodriguez, Gabbiadini, Long.
The win against Southampton came without injured star Harry Kane, with Eriksen reflecting that the whole team worked to compensate for his absence.
The South Coast outfit go into the weekend tenth in the table and having won their last two away games, scoring eight goals, so they are sure to make things hard for Pochettino's Spurs on Sunday.
Although Gabbiadini's unbelievable shooting has helped hugely in this department of late, Southampton's biggest problem remains converting their chances.
Generally Spurs do have a very good record against the Saints since they were promoted, and have only lost one game against them.
It was a marvellous goal, too, as Eriksen marauded through central midfield before letting fly and dispatching a strike into the far left corner of the Southampton goal. Pochettino believes that the Spurs underperformed in September because of the fact that the players were exhausted after the Euro Competition. But not for the next eight or nine games if he is out for that long.