The power forward had arthroscopic surgery to remove a loose body from his left knee according to a team release. Love was averaging 20 points and 11 rebounds per game.
Love, who recently missed some games with back spasms, has been having his best season with Cleveland.
The layup came just moments after James had nailed a step back three pointer. Love was a double-double machine, averaging 25.9 points and 12.4 rebounds in 2013-14 - his final season with the Wolves.
Still, the Cavaliers have been relying so heavily on James during the regular season because they value finishing first in the East, and Love's absence will make it more hard to earn. Per NBAwowy.com, Cleveland has been outscored by 4.5 points per 100 possessions with James on the bench.
The Eastern Conference has absorbed a jolt over the past couple of days with two top contenders making news which should create a good opportunity for the Pacers on Wednesday night. We all did. It finally got back to the point where he felt like, 'validate myself once again in this league.' And then he has an injury again. Whether it's him trying to show that they shouldn't have traded him or just his anger towards the team that he wished he was still on, Wiggins plays his best against the wine and gold. The Cavs fell to Golden State in six games in the NBA Finals.
Love's injury obviously means increased workloads for the likes of Tristan Thompson and Channing Frye, in addition to LeBron James shouldering a heavier load. "We've got guys that's ready".
Frye matched season highs with 21 points and 10 rebounds in his first start in place of Kevin Love and the Cavs beat the Timberwolves, 116-108, for their sixth win in their last seven games.
"It sucks for Kevin", James said before the game.
Maybe fretting about the future is more in line with human nature than appreciating the present - the reason why you see more shows about apocalypse scenarios than about gratitude journaling - but at some point, you can see where James' exasperation is coming from.
For now, Lue is not considering starting Derrick Williams, who was signed last week to a 10-day contract but is expected to finish the season in Cleveland.
Tuesday night's total is set at 218 points.